The Human Microcirculation

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Gutterman et al Regulation of the Human Microcirculation 159 Microcirculation

Tasked with providing nutrients and removing metabolic byproducts from virtually all living cells in the body, the microcirculation plays a critical but indirect role in tissue function. Herein lies a major challenge. The microcirculation must maximize the distribution of nutrients and oxygen by touching nearly every living cell, while minimizing the space it occupies to allow room for the netw...

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Tasked with providing nutrients and removing metabolic byproducts from virtually all living cells in the body, the microcirculation plays a critical but indirect role in tissue function. Herein lies a major challenge. The microcirculation must maximize the distribution of nutrients and oxygen by touching nearly every living cell, while minimizing the space it occupies to allow room for the netw...

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Gutterman et al Regulation of the Human Microcirculation 159 Microcirculation as a Window Into

Tasked with providing nutrients and removing metabolic byproducts from virtually all living cells in the body, the microcirculation plays a critical but indirect role in tissue function. Herein lies a major challenge. The microcirculation must maximize the distribution of nutrients and oxygen by touching nearly every living cell, while minimizing the space it occupies to allow room for the netw...

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Assessment of liver microcirculation in human cirrhosis.

Alterations in the liver microcirculation were characterized by use of the multiple-indicator dilution technique in 25 cirrhotic patients undergoing hemodynamic evaluation of portal hypertension. Hepatic vein outflow dilution curves were obtained after portal vein or hepatic artery injections of a vascular reference substance (labeled erythrocytes) and of diffusible substances (labeled albumin ...

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Effects of propofol on human microcirculation.

BACKGROUND It is increasingly believed that acute microvascular alterations may be involved in the development of organ dysfunction in critically ill patients. Propofol significantly decreases vascular tone and venous return, which can induce arterial hypotension. However, little is known about the microcirculatory effects of propofol in healthy humans. METHODS We conducted a prospective, ope...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 2016

ISSN: 0009-7330,1524-4571

DOI: 10.1161/circresaha.115.305364